Marca Wauben
Marca Wauben is full professor in cell biology (Chair: Intercellular communication) at the Department of Biomolecular Health Sciences, Division Cell Biology, Metabolism and Cancer, Faculty Veterinary medicine, Utrecht University, The Netherlands. She is a pioneer in EV research and an expert in deciphering the role of EVs in intercellular communication in biological systems with emphasis on the immune system. Her research group has unveiled novel aspects in EV biogenesis, regulation of EV release, specific targeting, and cargo incorporation (including RNA, proteins, and lipids) and by combining multi-omics with functional cellular modulation, the concept of EV-mediated modulation via the convergence of different EV-cargoes on nodes of regulation in cellular signal transduction pathways has been postulated. Her group pioneered in the development of single EV-analysis by high-resolution flow cytometry, which enabled advanced quantitative and qualitative analysis and sorting of nano-sized EVs, thereby moving from bulk-based EV analyses to EV-subset and single EV analyses. Besides investigating fundamental immunological and regenerative aspects of EV-mediated communication, her research groups works on EV-based biomarker discovery, (therapeutic) EV applications and the development of (nano)technology to analyze EVs. Wauben is author of > n=150 peer reviewed scientific publications on EVs and (Co-)recipient of multiple EV-based consortium research grants, e.g. FP7 EU COST Action Microvesicles and Exosomes in Health and Disease (2012, vice-chair), H2020-MSCA-ITN-2016 TRAIN-EV research and training Network (722148) (2017) and H2020-FETOPEN The EV Foundry (801367)(2018). She has been/and is involved in many national and global initiatives to build a scientific community centered around EV-biology; e.g. the founding of the International Society for Extracellular Vesicles (ISEV), the scientific journal “Journal of Extracellular Vesicles”, the founding of the ISEV-ISAC-ISTH EV flowcytometry working group (www.evflowcytometry.org) and the founding of the Netherlands Society for Extracellular Vesicles (NLSEV) in 2018 (founding President). She is co-chair of the ISEV Milk EV Task Force and member of ISEV Regulatory affairs and clinical use of EV-based therapeutics Task Force. In 2019 she was awarded the ISEV special Achievement Award and in 2020 the ISEV life-time membership Award.
Contact
Prof. Dr. Marca H.M. Wauben
Division Cell Biology, Metabolism and Cancer
Department of Biomolecular Health Sciences
Faculty Veterinary medicine
Utrecht University
Yalelaan 2
3584CM Utrecht
The Netherlands
Phone: +31639585529
E-mail: M.H.M.Wauben@uu.nl
https://www.uu.nl/en/research/life-sciences/marca-wauben